Table 2 Western blotting results for GABAA receptor subunits expressed as a ratio of β-actin in the lateral cerebella

From: Expression of GABAA α2-, β1- and ɛ-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder

 

ANOVA

Control

Schizophrenia

Bipolar disorder

Major depression

Lateral cerebellum

F-test

P-value

Protein

P-value

Protein

P-value

Protein

P-value

Protein

P-value

GABRα1/β-actin

1.46

NC

0.331±0.127

RG

0.507±0.311

NC

0.474±0.266

NC

0.486±0.252

0.049

GABRα2/β-actin

3.35

0.027

0.126±0.083

RG

0.370±0.282

0.0046

0.321±0.273

0.017

0.271±0.154

0.0047

GABRα3/β-actin

0.46

NC

0.196±0.076

RG

0.239±0.159

NC

0.236±0.161

NC

0.193±0.14

NC

GABRα5/β-actin

2.02

NC

0.031±0.02

RG

0.063±0.067

NC

0.04±0.03

NC

0.033±0.018

NC

GABRα6/β-actin

1.76

NC

0.013±0.003

RG

0.015±0.007

0.23

0.016±0.009

NC

0.019±0.005

0.001

GABRβ1/β-actin

6.03

0.001

0.135±0.049

RG

0.066±0.031

0.0001

0.092±0.048

0.026

0.092±0.047

0.023

GABRβ2/β-actin

1.56

NC

0.035±0.013

RG

0.030±0.016

NC

0.025±0.008

0.025

0.034±0.016

NC

GABRβ3 (upper) /β-actin

2.01

NC

0.114±0.136

RG

0.058±0.063

NC

0.152±0.084

NC

0.109±0.103

NC

GABRβ3 (lower) /β-actin

0.77

NC

0.57±0.16

RG

0.59±0.14

NC

0.60±0.19

NC

0.50±0.21

NC

GABRδ/β-actin

0.46

NC

0.032±0.017

RG

0.034±0.015

NC

0.027±0.021

NC

0.034±0.017

NC

GABRɛ/β-actin

8.88

0.0001

0.015±0.007

RG

0.035±0.029

0.044

0.041±0.018

0.0006

0.079±0.046

0.0003

GABRγ2/β-actin

0.74

NC

0.016±0.008

RG

0.015±0.009

NC

0.012±0.005

NC

0.012±0.006

NC

GABRγ3/β-actin

1.53

NC

0.099±0.052

RG

0.114±0.059

NC

0.137±0.072

NC

0.141±0.055

0.047

β-actin

0.83

NC

25.8±2.07

RG

25.2±2.07

NC

26.9±2.91

NC

26.1±4.38

NC

  1. Abbreviations: ANOVA, analysis of variance; GABAA, γ-aminobutyric acid (A); NC, no change; RG, reference group.
  2. Bold entries are significant P values.