Table 3 Western Blotting Results for GABA_A receptor subunits expressed as a ratio of NSE in lateral cerebella

	ANOVA		Control		Schizophrenia		Bipolar disorder		Major depression
Lateral cerebellum	F-test	P-value	Protein	P-value	Protein	P-value	Protein	P-value	Protein	P-value
GABRα1/NSE	1.19	NC	0.45±0.19	RG	0.60±0.28	NC	0.60±0.28	NC	0.56±0.21	NC
GABRα2/NSE	3.49	0.022	0.14±0.09	RG	0.32±0.19	0.0042	0.28±0.17	0.011	0.31±0.19	0.0063
GABRα3/NSE	0.81	NC	0.25±0.11	RG	0.25±0.17	NC	0.29±0.16	NC	0.21±0.10	NC
GABRα5/NE	2.00	NC	0.036±0.023	RG	0.071±0.076	NC	0.043±0.029	NC	0.037±0.020	NC
GABRα6/NSE	1.79	NC	0.026±0.007	RG	0.037±0.023	NC	0.031±0.018	NC	0.040±0.011	0.0023
GABRβ1/NSE	4.53	0.007	0.17±0.07	RG	0.084±0.048	0.001	0.11±0.064	0.034	0.11±0.066	0.03
GABRβ2/NSE	1.35	NC	0.039±0.015	RG	0.036±0.020	NC	0.028±0.007	0.022	0.035±0.013	NC
GABRβ3 (upper) /NSE	1.97	NC	0.11±0.13	RG	0.063±0.069	NC	0.16±0.10	NC	0.11±0.098	NC
GABRβ3 (lower) /NSE	1.80	NC	0.63±0.13	RG	0.65±0.13	NC	0.57±0.11	NC	0.55±0.13	NC
GABRδ/NSE	1.46	NC	0.038±0.022	RG	0.046±0.026	NC	0.028±0.016	NC	0.038±0.019	NC
GABRɛ/NSE	7.26	0.001	0.017±0.009	RG	0.037±0.032	NC	0.041±0.017	0.0013	0.084±0.056	0.0012
GABRγ2/NSE	0.40	NC	0.03±0.014	RG	0.029±0.018	NC	0.024±0.010	NC	0.029±0.021	NC
GABRγ3/NSE	1.33	NC	0.12±0.06	RG	0.13±0.08	NC	0.17±0.11	NC	0.16±0.07	NC
NSE	0.93	NC	20.2±2.34	RG	20.1±1.67	NC	20.2±3.34	NC	21.6±2.87	NC

Abbreviations: ANOVA, analysis of variance; GABA_A, γ-aminobutyric acid (A); NC, no change; NSE, neuronal specific enolase; RG, reference group.
Bold entries represent significant P values.

Quick links

Search