Translational Psychiatry

Table 5 Summary of mRNA and protein levels for selected GABA_A and GABA_B receptor subunits in cerebella from subjects with three major psychiatric disorders

From: Expression of GABA_A α2-, β1- and ɛ-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder

		Schizophrenia		Bipolar disorder		Major depression
Subunit	Chromosomal location	M	P	M	P	M	P
GABRα1	5q34–q35	↓	NC	NC	NC	↓	↑
GABRα2	4q13–p12	↓	↑	NC	↑	NC	↑
GABRα3	Xq28	NC	NC	NC	NC	NC	NC
GABRα5	15q11.2–q13	NC	NC	NC	NC	NC	NC
GABRα6	5q31.1–q35	NC	NC	NC	NC	NC	↑
GABRβ1	4q13–p12	NC	↓	NC	↓	NC	↓
GABRβ2	5q34–q35	NC	NC	NC	↓	NC	NC
GABRβ3	15q11.2–q13	↓	NC	NC	NC	NC	NC
GABRδ	1p36.3	NC	NC	NC	NC	NC	NC
GABRɛ	Xq28	NC	↑	NC	↑	NC	↑
GABRγ2	15q31.1–q33.1	NC	NC	NC	NC	NC	NC
GABRγ3	15q11.2–q13	NC	NC	NC	NC	NC	↑
GABBR1¹	6p21.3	NC	↓	NC	↓	NC	↓
GABBR2¹	6q12–q21	NC	↓	↑	↓	NC	↓

Abbreviations: GABBR1, GABA_B receptor subunit 1; GABBR2, GABA_B receptor subunit 2; M, mRNA; NC, no change; P, protein.
GABBR1 and GABBR2 data reprinted from Fatemi et al.,²⁹ with permission from Elsevier.

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