Figure 1 | Translational Psychiatry

Figure 1

From: Opposing actions of environmental enrichment and Alzheimer’s disease on the expression of hippocampal microRNAs in mouse models

Figure 1

Hippocampal microRNAs (miRNAs) global expression signature in young 3xTgAD mice model of Alzheimer’s disease (AD). General distribution of miRNAs modulation derived from young (4-month-old) mice model of AD compared with their age-matched wild-type (WT) C57BL/6J mice. (a) Distribution chart of miRNA changes showing miRNAs that were upregulated (Up), downregulated (Down) or unchanged (Unchanged). (b) Scatter-plot representation of miRNA expression changes. While most of the miRNAs were not modulated following exposure to enriched environment (EE) (presented around and on the regression line), some of the miRNAs were upregulated (below the regression line), and some were downregulated (above the regression line), compared with control mice. Values are presented as 1/threshold cycle (1/Ct). Properly detected miRNAs with Ct<40 and fold change >2 or <0.5 are presented. (c) Relative quantification (RQ) of miRNAs that were upregulated with RQ>2 or downregulated with RQ<−2.

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