Figure 4

microRNAs (miRNAs) global expression signature in the hippocampus of wild-type (WT) C57BL/6J mice following environmental enrichment. General distribution of miRNAs modulation derived from WT C57BL/6J mice that were environmentally enriched, as compared with WT C57BL/6J control mice that were exposed to regular environment. (a) Distribution chart of miRNA changes showing miRNAs that were upregulated (Up), downregulated (Down) or unchanged (Unchanged). (b) Scatter-plot representation of miRNA expression changes. While most of the miRNAs were not modulated following exposure to enriched environment (EE) (presented around and on the regression line), some of the miRNAs were upregulated (below the regression line), and some were downregulated (above the regression line), compared with control mice. Values are presented as 1/threshold cycle (1/Ct). Properly detected miRNAs with Ct<40 and fold change>2 or <0.5 are presented. (c) Relative quantification (RQ) of miRNAs that were upregulated with RQ>2 or downregulated with RQ<−2.