Figure 3 | Translational Psychiatry

Figure 3

From: Genome-wide expression profiling of human lymphoblastoid cell lines implicates integrin beta-3 in the mode of action of antidepressants

Figure 3

Hypothetical model depicting the cell membrane proteins encoded by CHL1 and SLC6A4 (SERT) competing on a limited pool of integrin beta-3 (ITGB3) protein. (a) At low CHL1 expression levels, more ITGB3 is available for supporting serotonin transporter (SERT) serotonin-uptake activity, hence higher sensitivity to SSRI drugs is observed. (b) At high CHL1 expression levels (and similar SERT and ITGB3 expression levels as depicted in panel a) more ITGB3 interacts with CHL1 and less ITGB3 is available for supporting SERT serotonin-uptake activity, hence lower sensitivity to SSRI drugs is observed.

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