Table 2 MicroRNAs whose expression was affected by chronic paroxetine exposure of LCLs

From: Genome-wide expression profiling of human lymphoblastoid cell lines implicates integrin beta-3 in the mode of action of antidepressants

MiRNA

Fold-change a

P value

miR-3195

1.527

8.90 × 10−8

miR-1246

2.406

7.01 × 10−6

miR-221

−1.525

7.22 × 10−6

miR-1290

4.001

1.42 × 10−5

miR-1263

−1.411

8.36 × 10−5

miR-550-star

−1.428

8.63 × 10−5

miR-29c-star

1.640

2.68 × 10−4

miR-3178

1.440

3.95 × 10−4

miR-222

−1.416

5.07 × 10−4

miR-664

−1.615

5.19 × 10−4

  1. Abbreviations: LCLs, lymphoblastoid cell lines; miRNA, micro RNA.
  2. The 10 listed miRNAs exhibited >1.4-fold difference and P<0.001 in expression levels in four LCLs following treatment for 21 days with 1 μM paroxetine.
  3. aFold-change represents expression levels following paroxetine exposure compared with controls grown and studied by microarrays in parallel. As shown, one half of these top miRNAs were upregulated by chronic paroxetine exposure. Expression levels were determined with whole-genome expression microarrays and miRNAs are arranged by increasing P-values. The expression differences for two selected miRNAs (in bold font) were confirmed by real-time PCR experiments (Figure 2). According to PubMed search (27 May 2013) the only miRNAs in this list reportedly expressed in the human brain are miR-221 and miR-222.
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