Table 1 Clock gene SNPs and MAF in BD cases and controls

From: Genetic and clinical factors predict lithium’s effects on PER2 gene expression rhythms in cells from bipolar disorder patients

Gene

SNP

MAF Cont

MAF BD

Notes

BMAL1

rs2279287

31.6

13.2

Assoc BD, AKA ARNTL38

CLOCK

rs1801260

31.6

26.3

Assoc BD and insomnia32

CRY1

rs8192440

26.3

28.9

Assoc Li response18

CRY2

rs2037311

2.6

2.6

 

CSNK1E

rs1534891

13.2

10.5

 

GSK3β

rs334558

28.9

28.9

Assoc Li response13, 14

NPAS2

rs11541353

18.4

23.7

Assoc SAD, AKA S471L33

Rev-Erbα

rs2071427

18.4

18.4

Assoc Li response,18 AKA NR1D1

PER1

rs3027178

15.8

26.3

 

PER2

rs56013859

15.8

26.3

Assoc SAD,33 AKA 10870

PER3

rs228729

36.8

26.3

Assoc BD,38 tags VNTR

RORA

rs12912233

44.7

39.5

Assoc depression31

  1. Abbreviations: Assoc, associated; AKA, also known as; MAF, minor allele frequency; SAD, seasonal affective disorder; SNP, single-nucleotide polymorphism; VNTR, variable number tandem repeat.
  2. In some instances, past illness associations and reference are indicated. Also known as (AKA) indicates alternate name for SNP or gene.
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