Figure 1 | Translational Psychiatry

Figure 1

From: Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding

Figure 1

Effects of CACNA1C and PCLO depression risk variants on self-referential memory encoding (Experiment 1). (a) Experimental paradigm. Participants studied adjectives describing personality traits and performed either a self-reference task (‘Self’), an other-reference task (‘Merkel’) or a control task (syllable counting). Stimuli were presented in a pseudo-randomized order with a near-exponential temporal jitter to optimize estimation of trial-specific BOLD responses. (b) Interaction of CACNA1C and PCLO depression risk variants on subgenual cingulate activation. Carriers of both high-risk alleles (CACNA1C rs1006737 A and PCLO rs2522833 C) exhibited comparable CG25 activation as participants homozygous for both low-risk alleles (CACNA1C rs1006737 G and PCLO rs2522833 A), whereas CG25 activity was drastically reduced in carriers of either one high-risk allele. The activation difference in CG25 was significant after family-wise error (FWE) correction for the ROI volume. Bar plots depict contrasts of parameter estimates (SPM betas) scaled to the global mean, ±s.e. ROI, region of interest; SPM, statistical parametric mapping.

Back to article page