Figure 2

Effects of CACNA1C and PCLO depression risk variants on associative memory encoding (Experiment 2). (a) Experimental paradigm. The task was divided into three phases (encoding, recall, recognition). During encoding, participants studied face–profession associations (left). In the recall task, participants were asked to recall the profession associated with the face and decide whether this profession required academic studies or vocational training (center). During recognition, participants performed a two-alternative forced choice task deciding which profession had been presented with the face (right). Translations: Architektin—architect; Studium—academic studies; Lehre—vocational training; Apothekerin—pharmacist. Stimuli were presented as blocked design. (b) Interaction of CACNA1C and PCLO depression risk variants on subgenual cingulate activation. Carriers of both high-risk alleles exhibited comparable CG25 activation as participants homozygous for both low-risk alleles, whereas CG25 activation was lower in carriers of either one high-risk allele. The CACNA1C by PCLO genotype interaction in CG25 was significant after family-wise error (FWE) correction for the ROI volume. Bar plots depict contrasts of parameter estimates (SPM betas), ±standard error.