Figure 3 | Translational Psychiatry

Figure 3

From: Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding

Figure 3

Effects of CACNA1C and PCLO depression risk variants on encoding of novel scenes (Experiment 3). (a) Experimental paradigm. Participants studied novel scenes intermixed with previously familiarized ‘master’ scenes and were asked to respond via button press whether an indoor or outdoor scene was shown. Stimuli were presented in a pseudo-randomized order with a near-exponential temporal jitter to optimize estimation of trial-specific BOLD responses. (b) Interaction of CACNA1C and PCLO depression risk variants on subgenual cingulate activation. Carriers of both high-risk alleles exhibited comparable CG25 activation as participants homozygous for both low-risk alleles, whereas CG25 activation was lower in carriers of either one high-risk allele. The CACNA1C by PCLO genotype interaction in CG25 was significant after family-wise error (FWE) correction for the ROI volume. Bar plots depict contrasts of parameter estimates (SPM betas), ±s.e. ROI, region of interest; SPM, statistical parametric mapping.

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