Table 1 Enriched in iPSC

From: Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients

 

BP iPSC

Control iPSC

GO term

n

P*⩽

n

P*⩽

Blastocyst development

32

5.1 × 10−4

27

2.1 × 10−3

Post-transcriptional regulation of gene expression

109

5.1 × 10−3

109

2.3 × 10−3

In utero development

90

2.5 × 10−2

85

4.2 × 10−3

  1. Abbreviations: BP, bipolar disorder;
  2. GO, Gene Ontology; iPSC, induced pluripotent stem cells; *, Bonferroni correction.
  3. iPSC from BP and control individuals expressed very similar sets of transcripts compared with neurons differentiated from them. Functional Chart analysis identified comparable sets of GO terms and similar transcripts in each category, particularly genes associated with early embryonic development.
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