Table 3 Analysis of iPSCs

From: Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients

i. Increased in BP iPSC

ii. Increased in C iPSC

GO term

n

P*⩽

GO term

n

P*⩽

Embryonic morphogenesis

17

9.0 × 10−5

TGFβ related

4

5.7 × 10−4

Signal

57

6.1 × 10−4

   

Axonogenesis

10

9.4 × 10−3

   

Appendage development

8

6.7 × 10−3

   

Skeletal system development

12

1.7 × 10−2

   

Cell adhesion

20

6.7 × 10−3

   

Female gonad development

7

6.1 × 10−3

   

Skeletal system morphogenesis

7

3.0 × 10−2

   

Positive regulation of developmental process

13

4.9 × 10−3

   

Cell–cell adhesion

10

4.9 × 10−2

   

Transcription from PolII

18

3.0 × 10−2

   

Blood vessel development

10

2.8 × 10−2

   

Transcription regulation

36

2.2 × 10−2

   

Tube development

9

4.5 × 10−2

   
  1. Abbreviations: BP, bipolar disorder; C, control; GO, Gene Ontology; iPSC, induced pluripotent stem cells; TGFβ, transforming growth factor-β; *, Bonferroni correction. i: Functional Annotation Cluster analysis identified 14 clusters of transcripts that were expressed at significantly higher levels in BP vs control iPSC, most associated with early development. ii: A single cluster of transforming growth factor-β-related transcripts was expressed at significantly higher levels in control iPSC.
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