Figure 2
Behavioral responses of db/db mice to fluoxetine and desipramine in the forced swim test. (a) Behavioral effects of acute treatment with fluoxetine (10 mg kg−1, i.p.) and desipramine (10 mg kg−1, i.p.). Forced swim test and locomotor activity test were performed 30 min after injection. (a1) Left panel, forced swim test; right panel, locomotor activity test. (a2) Left panel, forced swim test; right panel, locomotor activity test. (b) Behavioral effects of chronic administration with fluoxetine (10 mg kg−1 per day, i.p.), desipramine (10 mg kg−1 per day, i.p.) for 21 days. The forced swim test was carried out 24 h after the last injection. n=7–13 per group. *P<0.05, **P<0.01, ***P<0.001 compared with vehicle-treated wild-type (WT) mice; #P<0.05 compared with vehicle-treated db/db mice. i.p., intraperitoneal.
