Figure 4
Effects of acute desipramine treatment on phosphorylation of Akt, GSK3β and ERK1/2 in the hippocampus, PFC and hypothalamus of db/db mice versus wild-type mice. Phosphorylation of Akt, GSK3β and ERK1/2 was determined 30 min after acute desipramine treatment (20 mg kg−1, i.p.). (a) Upper panel showing representative immunoblots of Akt, GSK3β and ERK1/2 in the hippocampus of wild-type (WT) mice and db/db mice. Bottom panel showing quantitative data. (b) Phosphorylation of Akt, GSK3β and ERK1/2 in the PFC of wild-type mice. (c) Phosphorylation of Akt, GSK3β and ERK1/2 in the hypothalamus of wild-type mice. n=4 per group. i.p., intraperitoneal.
