Figure 5
Behavioral responses of Lepr cKO mice to fluoxetine and desipramine. The Lepr cKO mice and littermate control (fWT) mice received acute treatment with fluoxetine (10 mg kg−1, i.p.) and desipramine (10 mg kg−1, i.p.). Forced swim test or tail suspension test was performed 30 min after injection. (a) Forced swim test. Left panel, fluoxetine produces antidepressant-like behavioral effect in control mice but not in Lepr cKO mice. Right panel, desipramine produces similar behavioral effects in Lepr cKO mice and control mice. (b) Tail suspension test showing similar results. Left panel, behavioral response of Lepr cKO mice to fluoxetine. Right panel, behavioral response of Lepr cKO mice to desipramine. n=7–15 per group, *P<0.05, **P<0.01, ***P<0.001 compared with vehicle-treated control mice. ###P<0.001 compared with vehicle-treated Lepr cKO mice. i.p., intraperitoneal.
