Figure 3
From: Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines
Clustering of lymphoblastoid cell lines (LCLs) derived from children with autistic disorder (AD) into two subgroups: the AD-N subgroup has mitochondrial respiratory profiles similar to controls and the AD-A subgroup has atypical mitochondrial respiratory profiles. (a) AD-N cases (green circles) and AD-A cases (red diamonds) represent the two subgroups. The AD-N subgroup demonstrates a negative correlation between adenosine-5’-triphosphate (ATP)-linked respiration and proton-leak respiration (r=−0.77, P<0.01, green line) whereas the AD-A group demonstrates a positive correlation between ATP-linked respiration and proton-leak respiration (r=0.44, P=NS, red line). If the two outliers are removed from the AD-N group, the correlation is still significant (r=−0.86, P<0.01; blue line). (b) Individual (thin lines) and overall (thick green dashed line) change in ATP-linked respiration for the AD-N groups. Notice that there is little change overall. (c) Individual (thin lines) and overall (thick green dashed line) change in proton-leak respiration for the AD-N groups. Notice that there is little change overall. (d) Individual (thin lines) and overall (thick red dashed line) change in ATP-linked respiration for the AD-A groups. Notice that, overall, ATP-linked respiration increases with DMNQ concentration. (e) Individual (thin lines) and overall (thick red dashed line) change in proton-leak respiration for the AD-A groups. Notice that, overall, proton-leak respiration increases with DMNQ concentration. DMNQ, 2,3-dimethoxy-1,4-napthoquinone; NS, not significant.
