Table 3 Unstandardized effect sizes (s.e.) of the group × time × SNP interaction and their P-values

SNP	Gene	Effect size (s.e.)	P-value
rs6265	BDNF	−0.067 (0.082)	0.415
rs11030101	BDNF	0.274 (0.089)	0.002^a
rs11030102	BDNF	0.128 (0.081)	0.112
rs4680^b	COMT	(a) 0.204 (0.097) (b) −0.049 (0.110) (c) −0.254 (0.092)	0.0360.6560.006
rs4818	COMT	−0.063 (0.085)	0.461
rs6269	COMT	−0.104 (0.086)	0.229
rs324650	CHRM2	−0.206 (0.087)	0.018
rs1824024^c	CHRM2	−0.259 (0.083)	0.002^a
rs6276	DRD2	−0.206 (0.079)	0.010
rs6277	DRD2	−0.156 (0.090)	0.082
rs936461	DRD4	0.426 (0.082)	0.000^a
rs495491^d	OPRM1	0.372 (0.081)	0.000^a
rs609148^e	OPRM1	0.647 (0.083)	0.000^a
rs6347	SLC6A3	−0.209 (0.081)	0.009

Abbreviations: BDNF, brain-derived neurotrophic factor; CHRM2, cholinergic receptor muscarinic 2; COMT, catechol-O-methyltransferase; DRD2, dopamine receptor D2; DRD4, dopamine receptor D4; OPRM1, μ1 opioid receptor; SLC6A3, dopamine transporter; SNP, single nucleotide length polymorphism.
Note: the most common homozygotic genotype is the reference category (except for rs4680, of which the homozygote of the non-risk allele is the reference category); (a) tests group 1 to 0 (heterozygotic genotype to homozygote of non-risk allele), (b) tests group 2 to 0 (homozygote of risk-allele to homozygote of non-risk allele), (c) tests group 2 to 1 (homozygote of risk-allele to heterozygotic genotype).
^aIndicates a significant result, that is when P-values are ordered from smallest P₁ to largest P_n, Pi ⩽α/(n−i+1), following Holm’s method for correcting for multiple testing.^54,55
^brs4680 is perfectly correlated with rs4633 and highly correlated with rs4818 and rs6269.
^crs1824024 is highly correlated with rs2061174.
^drs495491 is highly correlated with rs3823010.
^ers609148 is perfectly correlated with rs648893.

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