Figure 1

Parallel plots of fold change values for the 14 694 analyzable genes at both 24 and 48 h. The four graphs are for each combination of significance at 24 and 48 h time points (q<0.05). In each graph, the x axis shows fold changes (FCs) at 24 and 48 h time points, log₂ (FC₂₄) and log₂ (FC₄₈). The y axis is log₂ FC with positive values indicating upregulation upon overexpression of miR-137 and negative values the opposite. Each line connects the log₂ FC values for a gene. Large FC values may not be statistically significant (can occur when expression levels are low). All lines in a are colored gray. For b–d, red lines indicate inhibition at both 24 and 48 h, green lines increased expression at both 24 and 48 h and grey lines show genes whose log₂ FC values switched signs between 24 and 48 h.