Table 1 DAVID pathway analysis of differentially expressed genes (q<0.1)
From: Transcriptional targets of the schizophrenia risk gene MIR137
Time | Direction of effect | Enrichment | Annotation cluster description |
|---|---|---|---|
24 h | Downregulation (183 genes) | 3.04 | Extracellular matrix |
2.92 | Positive regulation of transcription | ||
2.61 | Neuron differentiation/projection | ||
2.55 | Extracellular signaling | ||
Upregulation (126 genes) | 2.75 | Cell cycle | |
48 h | Downregulation (239 genes) | 10.75 | Cell cycle |
7.16 | DNA replication | ||
4.74 | Lumen/membrane enclosed | ||
4.42 | Cell cycle checkpoint | ||
3.31 | Chromosome segregation | ||
3.04 | Mitotic checkpoint/chromosome | ||
3.01 | Microtubule/spindle organization | ||
2.79 | DNA binding | ||
Upregulation (376 genes) | 15.98 | Signaling | |
12.07 | Transmembrane | ||
10.47 | Cell adhesion | ||
5.87 | Plasma membrane | ||
4.41 | EGF-like | ||
4.18 | MHC class II/antigen processing | ||
3.89 | Ion transport/gated channels | ||
3.79 | Immunoglobulin-like | ||
3.63 | Calcium ion binding/ion binding | ||
3.21 | Angiogenesis | ||
2.80 | Cell junction/synapse | ||
2.58 | Synaptic transmission | ||
2.55 | Matrix adhesion/integrins | ||
2.52 | Extracellular matrix |
