Table 2 Analyses of pathways implicated by schizophrenia genome-wide studies

From: Transcriptional targets of the schizophrenia risk gene MIR137

Pathway

DE genes (q<0.1)

24 h

48 h

  

P

OR (95% CI)

P

OR (95% CI)

Synaptic genes

All

0.90

0.94 (0.57–1.56)

2.8 × 10 −7

2.13 (1.63–2.78)

(1043 genes)

Downregulated

0.86

0.85 (0.41–1.74)

1.0

0.95 (0.5–1.81)

 

Upregulated

0.70

1.11 (0.54–2.28)

3.2 × 10 −8

2.54 (1.88–3.44)

Postsynaptic

All

0.78

0.88 (0.49–1.58)

0.06

1.4 (0.99–1.99)

density

Downregulated

1.0

0.86 (0.38–1.97)

0.39

0.63 (0.28–1.44)

(1457 genes)

Upregulated

1.0

0.98 (0.43–2.24)

0.0049

1.82 (1.23–2.71)

ARC

All

1.0

N/A

0.0096

5.51 (1.86–16.32)

(28 genes)

Downregulated

1.0

N/A

0.20

4.96 (0.61–40.5)

 

Upregulated

1.0

N/A

0.03

5.03 (1.4–18.09)

NMDA receptor

All

1.0

0.89 (0.12–6.45)

0.17

1.94 (0.7–5.38)

(61 genes)

Downregulated

1.0

N/A

0.24

2.24 (0.53–9.43)

 

Upregulated

0.41

1.94 (0.26–14.27)

0.32

1.84 (0.43–7.88)

FMRP interactors

All

0.08

1.49 (0.96–2.32)

4.7 × 10 −5

1.92 (1.43–2.57)

(842 genes)

Downregulated

0.07

1.61 (0.98–2.65)

0.71

1.13 (0.57–2.21)

 

Upregulated

1.0

0.84 (0.31–2.28)

1.5 × 10 −4

1.98 (1.42–2.75)

Calcium channel

All

1.0

N/A

0.0056

6.61 (2.19–19.97)

subunits

Downregulated

1.0

N/A

1.0

N/A

(26 genes)

Upregulated

1.0

N/A

0.0098

5.68 (1.84–17.52)

Cav2 interactors

All

0.08

N/A

0.11

1.68 (0.9–3.1)

(207 genes)

Downregulated

0.27

N/A

0.73

0.47 (0.06–3.36)

 

Upregulated

0.65

N/A

0.04

2.09 (1.08–4.05)

  1. Abbreviations: ARC, neuronal activity-regulated cytoskeleton-associated protein postsynaptic signaling complexes; Cav2, voltage-gated calcium channel; CI, confidence interval; DE, differentially expressed; FMRP, fragile X mental retardation protein; NMDA, N-methyl-D-aspartate; OR, odds ratio. Boldface shows P<0.01.
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