Table 3 Enrichment of schizophrenia GWAS results and genes with differential expression after overexpression of miR-137

From: Transcriptional targets of the schizophrenia risk gene MIR137

Time

DE genes (q<0.1)

Enrichment P-value

24 h

All

>0.1

 

Downregulation

>0.1

 

Upregulation

>0.1

48 h

All

0.014

 

Downregulation

0.005

 

Upregulation

0.011

  1. Abbreviation: GWAS, genome-wide association study.
  2. P-values from INRICH evaluating the enrichment of lower GWAS P-values (P<0.01)6 to differentially expressed genes (q<0.1) from miR-137 overexpression. The extended major histocompatibility complex region (chr6:25–34 mb) was excluded due to its high gene density, extended linkage disequilibrium and strong GWAS signal in schizophrenia. Boldface shows P<0.01.
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