Figure 2 | Translational Psychiatry

Figure 2

From: Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia

Figure 2

The prototypical Th1 cytokine ccr5 (a) significantly differed across the three groups (P=0.015; Kruskal–Wallis test, Bonferroni-corrected) and was downregulated in BD patients compared with HC (P=0.02) but not to SCZ patients (P=0.26; Mann–Whitney U-test, Bonferroni-corrected). The prototypical Th2 cytokine ccl2 (b) and il4 mRNA (c) and the T-regulatory cell marker tgfβ (d) were significantly different among the three groups (P=0.036, P=0.002 and P=0.001, respectively). In particular, BD patients had downregulated ccl2 and tgfβ compared with controls (P=0.006 and P=0.004, respectively) and individuals with SCZ (P=0.003 and P=0.007, respectively) and upregulated il4 compared with HC (P=0.04) but not to SCZ patients (P=0.145; Mann–Whitney U-test, Bonferroni-corrected).

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