Table 2 Classification of the analyzed immune genes according to the M1/M2 paradigm (see references 62,63,64,65,66)

From: Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia

Gene

Phenotype

ccl1

M2b

ccl2

Both M1 and M2

ccl3

M1

ccl4

M1

ccl5

M1

ccl11

M2

ccl20

No confirmed association

ccl22

M2

cxcl10

M1

cc3

No confirmed association

ccr4

No confirmed association

ccr5

M1

ccr6

No confirmed association

ccr7

M1

cxcr5

No confirmed association

il1α

M1

il1β

M1

il4

M2

il6

M1

il10

M2

il17

No confirmed association

ifnγ

M1

tgfβ

No confirmed association

tnfα

M1

CD25/il2ra

No confirmed association

foxp3

No confirmed association

  1. It should be noted that not all the analyzed genes have been clearly linked to one of the two activation phenotypes. In addition, genes that have been linked to monocyte/macrophage polarization can have important roles in other cell types such as T-helper cells.
Back to article page