Figure 3 | Translational Psychiatry

Figure 3

From: Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation

Figure 3

Whole brain decreases in AEA correlate with increased anxiety in the light–dark box test. Linear regression analyses reveal significant correlations between whole brain AEA levels in control and stressed mice and (a) light-zone entries, (c) light-zone distance traveled as a percent of total distance traveled, (e) light-zone time and (g) total distance traveled. After PF-3845 treatment, however, the same measures no longer correlate with AEA levels (b, d, f and h), suggesting a saturation of AEA effects on anxiety at supraphysiological levels. Linear regression (solid line) with 95% confidence intervals (dashed lines) shown in figures. AEA, N-arachidonylethanolamine.

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