Figure 3 | Translational Psychiatry

Figure 3

From: Early life adversity and serotonin transporter gene variation interact at the level of the adrenal gland to affect the adult hypothalamo-pituitary-adrenal axis

Figure 3

Adrenocorticotropic hormone receptor (a, ACTH-R), 11β-hydroxylase (b, cytochrome P450 11B1/3, CYP11B1/3) and tyrosine hydroxylase (c) mRNA levels in the adrenal glands of serotonin transporter (5-HTT) homozygous knockout (5-HTT−/−), heterozygous knockout (5-HTT+/−) and wild-type (5-HTT+/+) rats (n=7) exposed to daily 3 h separations (MS180) or a control treatment (MS0). The mRNA levels of both ACTH-R and CYP11B1/3 were found to be significantly affected by the interaction of 5-HTT genotype and early life treatment (P<0.01, P<0.001, respectively). Data were normalized to the average of the MS0-5-HTT+/+ group. *P<0.05, **P<0.01, ***P<0.001.

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