Figure 4 | Translational Psychiatry

Figure 4

From: Early life adversity and serotonin transporter gene variation interact at the level of the adrenal gland to affect the adult hypothalamo-pituitary-adrenal axis

Figure 4

Corticosterone (CORT) response to 10−12 M adrenocorticotropic hormone (ACTH), of adrenal tissue derived from serotonin transporter (5-HTT), homozygous knockout (5-HTT−/−), heterozygous knockout (5-HTT+/−) and wild-type (5-HTT+/+) rats (n=6), which were reared in standard animal facility conditions. The CORT response was measured in vitro, in a static incubation system from which samples were collected every 15 min. *, 5-HTT−/− significantly different from 5-HTT+/+ (P<0.05, one-sided t-test).

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