Figure 1 | Translational Psychiatry

Figure 1

From: Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study

Figure 1

Hypothesized model outlining the tests for meditational effects. Path a (L or R) is the effect of 5-HTTLPR on the volume of a particular (left or right) brain region of interest (ROI), path b (L or R) is the effect of the volume of a particular (left or right) ROI on major depressive disorder (MDD) onset, path c is the total effect of 5-HTTLPR on MDD onset (that is, not controlling for left and right region of interest (ROI) volume), and path c is the direct effect of 5-HTTLPR on MDD onset (that is, controlling for left and right ROI volume).

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