Table 2 Path model of the effects of 5-HTTLPR genotype and brain ROIs on MDD onset

From: Association between serotonin transporter genotype, brain structure and adolescent-onset major depressive disorder: a longitudinal prospective study

 

b

s.e.

β

P

Hippocampus

 5-HTTLPR → MDD onset (path c′)

−0.21

0.17

−0.15

0.22

 5-HTTLPR → left hippocampus (path a)

−0.08

0.03

−0.18

0.03

 Left hippocampus → MDD onset (path b)

−1.79

0.79

−0.53

0.02

 5-HTTLPR → right hippocampus (path a)

−0.05

0.04

−0.12

0.16

 Right hippocampus → MDD onset (path b)

2.10

0.72

0.63

0.004

Amygdala

 5-HTTLPR → MDD onset (path c′)

−0.17

0.16

−0.12

0.30

 5-HTTLPR → left amygdala (path a)

0.01

0.02

0.04

0.66

 Left amygdala → MDD onset (path b)

1.44

1.08

0.31

0.18

 5-HTTLPR → right amygdala (path a)

0.02

0.03

0.07

0.42

 Right amygdala → MDD onset (path b)

−1.23

0.88

−0.29

0.16

Medial OFC

 5-HTTLPR → MDD onset (path c′)

−0.21

0.17

−0.15

0.23

 5-HTTLPR → left medial OFC (path a)

−0.46

0.21

−0.21

0.03

 Left medial OFC → MDD onset (path b)

−0.02

0.15

−0.04

0.88

 5-HTTLPR → right medial OFC (path a)

−0.51

0.19

−0.25

0.006

 Right medial OFC → MDD onset (path b)

−0.04

0.16

−0.05

0.83

Lateral OFC

 5-HTTLPR → MDD onset (path c′)

−0.19

0.16

−0.13

0.25

 5-HTTLPR → left lateral OFC (path a)

−0.10

0.37

−0.03

0.79

 Left lateral OFC → MDD onset (path b)

−0.06

0.11

−0.15

0.59

 5-HTTLPR → right lateral OFC (path a)

−0.01

0.32

−0.003

0.98

 Right lateral OFC → MDD onset (path b)

0.06

0.12

0.14

0.61

Limbic ACC

 5-HTTLPR → MDD onset (path c′)

−0.12

0.17

−0.08

0.49

 5-HTTLPR → left limbic ACC (path a)

−0.39

0.20

−0.17

0.06

 Left limbic ACC → MDD onset (path b)

0.16

0.08

0.27

0.04

 5-HTTLPR → right limbic ACC (path a)

−0.33

0.22

0.01

0.87

 Right limbic ACC → MDD onset (path b)

−0.02

0.08

−0.04

0.79

Paralimbic ACC

 5-HTTLPR → MDD onset (path c′)

−0.17

0.16

−0.12

0.29

 5-HTTLPR → left paralimbic ACC (path a)

0.13

0.23

0.05

0.58

 Left paralimbic ACC → MDD onset (path b)

−0.09

0.08

−0.16

0.25

 5-HTTLPR → right paralimbic ACC (path a)

0.05

0.22

0.02

0.82

 Right paralimbic ACC → MDD onset (path b)

0.09

0.08

0.15

0.28

  1. Abbreviations: ACC, anterior cingulate cortex; MDD, major depressive disorder; ROI, region of interest.
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