Table 2 TOMM40 ‘523’ poly-T repeat length genotype and cognitive ability—adjusted for age 11 IQ

From: Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Cognitive test

Step 1 Whole sample

Step 2 ɛ3/ɛ4 genotype subgroup only

Step 3 ɛ3/ɛ3 genotype subgroup only

 

(d.f.) F statistics

P

Partial η2

(d.f.) F statistics

P

Partial η2

(d.f.) F statistics

P

Partial η2

General factor: intelligence (g)

5, 753=1.52

0.182

0.010

(1, 186)=1.04

0.309

0.006

(2, 418)=0.92

0.401

0.004

Digit span backwards

5, 762=0.08

0.995

0.001

(1, 187)=0.07

0.786

0.000

(2, 426)=0.74

0.476

0.003

Matrix reasoning

5, 761=0.73

0.602

0.005

(1, 187)=1.02

0.314

0.005

(2, 425)=0.56

0.572

0.003

Block design

5, 760=1.39

0.228

0.009

(1, 187)=0.25

0.618

0.001

(2, 424)=1.31

0.277

0.006

Letter-number sequencing

5, 761=1.19

0.312

0.008

(1, 187)=4.51

0.035

0.024

(2, 425)=1.39

0.250

0.007

General factor: processing speed (gspeed)

5, 723=0.93

0.463

0.006

(1, 173)=0.31

0.578

0.002

(2, 407)=0.30

0.739

0.001

Digit symbol coding

5, 760=0.93

0.459

0.006

(1, 187)=0.31

0.578

0.002

(2, 424)=0.89

0.410

0.004

Symbol search

5, 757=1.18

0.316

0.008

(1, 186)=0.00

0.951

0.000

(2, 422)=0.37

0.692

0.002

Simple reaction time (seconds)

5, 754=0.55

0.741

0.004

(1, 185)=0.42

0.518

0.002

(2, 421)=1.25

0.287

0.006

Four-choice reaction time (seconds)

5, 758=0.35

0.880

0.002

(1, 186)=0.84

0.462

0.004

(2, 424)=0.44

0.646

0.002

Inspection time

5, 736=2.13

0.060

0.014

(1, 177)=2.26

0.135

0.013

(2, 414)=0.20

0.820

0.001

General factor: memory (gmemory)

5, 746=2.11

0.063

0.014

(1, 183)=0.17

0.685

0.001

(2, 416)=0.79

0.457

0.004

Logical memory

5, 760=2.13

0.060

0.014

(1, 186)=0.27

0.601

0.001

(2, 425)=2.33

0.099

0.011

Verbal paired associates

5, 748=0.95

0.449

0.006

(1, 184)=0.02

0.891

0.000

(2, 417)=1.09

0.337

0.005

Spatial span

5, 758=2.31

0.043

0.015

(1, 187)=3.09

0.081

0.016

(2, 422)=1.25

0.288

0.006

  1. Age in days at the time of testing, gender and age 11 IQ statistically controlled. Associations significant at P<0.05 are in bold.