Table 3 Intercorrelations between cognitive ageing and white matter tract variables that are each significantly associated with APOE ɛ genotype

From: Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

r (P-value)

Right ventral cingulum FA

Left inferior longitudinal fasciculus FA

General factor: intelligence (g)

0.02 (0.347)

0.20 (<0.001)

Matrix reasoning

−0.01 (0.411)

0.10 (0.008)

General factor: processing speed (gspeed)

0.04 (0.196)

0.17 (<0.001)

Digit symbol coding

0.03 (0.276)

0.18 (<0.001)

Symbol search

−0.03 (0.240)

0.11 (0.004)

Inspection time

0.07 (0.042)

0.14 (<0.001)

General factor: memory (gmemory)

0.01 (0.441)

0.08 (0.024)

Logical memory

0.02 (0.328)

0.05 (0.131)

Spatial span

−0.02 (0.334)

0.09 (0.015)

  1. Abbreviation: FA, fractional anisotropy.
  2. Pearson semi-partial correlations controlling for age, gender and age 11 IQ. Figures reflect ‘r’ correlations. FA, fractional anisotropy. Significant correlations in bold reflect a significant correlation (P<0.05) where both variables are also associated with APOE ɛ4 independent of vascular disease history (Supplementary Table 3).
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