Figure 1 | Translational Psychiatry

Figure 1

From: Peripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen

Figure 1

Both peripheral LPS administration and neuronal GSK-3β overexpression produced brain inflammation. (a–f) Representative images of microglial Iba1+ cells in different experimental conditions and their respective high magnification images. (g) Number of Iba1+ cells in the dentate gyrus. Both LPS-treated (a–b) and GSK-3-OE (e) mice showed a marked brain proinflammatory phenotype and an increased number of activated Iba1+ microglial cells. Ibuprofen treatment reduced the number of Iba1+ cells in all the experimental groups (c, d, f, g). (**, 0.001<P<0.01) (!, 0.05<P<0.1). White asterisks indicate microglial cells showing a resting morphological phenotype. Red asterisks indicate microglial cells showing an activated morphological phenotype. DG, dentate gyrus; LPS, lipopolysaccharide; PBS, phosphate-buffered saline; WT, wild type.

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