Table 2 Association results for the most significant of 455 SNPs in CTNNBL1 with episodic memory performance measures in the BASE-II cohort

From: No association between CTNNBL1 and episodic memory performance

Trait

rs number

Position

A1

A2

Maf

P-raw

P-adjusted

Beta

s.e.

SRFOBK (young)

rs913966

36309922

G

C

0.06179

0.05215

1

−0.2877

0.1476

SRFOBK (old)

rs6095709

36305770

G

A

0.07161

0.00556

1

−0.2320

0.08374

SRFO (young)

rs6063608

36430407

G

A

0.2170

0.07103

1

−0.1430

0.07904

SRFO (old)

rs6095709

36305770

G

A

0.07189

0.00992

1

−0.2148

0.08332

SRFO_P1 (young)

rs1123291

36529854

G

A

0.06437

0.02447

1

0.3400

0.1504

SRFO_P1 (old)

rs198490

36273719

C

T

0.4420

0.07607

1

−0.07010

0.03948

SRFO_P2 (young)

rs6091461

36530906

A

G

0.2691

0.04901

1

−0.1571

0.07968

SRFO_P2 (old)

rs62201719

36517381

A

G

0.4643

0.0220

1

0.08988

0.03922

SRFO_P3 (young)

rs913966

36309922

G

C

0.06179

0.04872

1

−0.2934

0.1483

SRFO_P3 (old)

rs6095709

36305770

G

A

0.07161

0.01647

1

−0.2021

0.08441

SRBK (young)

rs913966

36309922

G

C

0.06179

0.03835

1

−0.3092

0.1486

SRBK (old)

chr20:36488508:D

36488508

TCTCA

T

0.2581

0.01418

1

0.1111

0.04525

SRBK_P1 (young)

rs11698255

36531400

G

A

0.07086

0.01179

1

0.3643

0.1438

SRBK_P1 (old)

rs2144768

36501221

G

A

0.2809

0.00200

1

0.1437

0.04640

SRBK_P2 (young)

rs913966

36309922

G

C

0.06179

0.11507

1

−0.2382

0.1511

SRBK_P2 (old)

rs73290822

36325944

C

T

0.05222

0.05189

1

0.1739

0.08966

SRBK_P3 (young)

rs913966

36309922

G

C

0.06179

0.02859

1

−0.31934

0.1453

SRBK_P3 (old)

rs75642402

36423858

T

C

0.06549

0.00502

1

−0.24575

0.0880

Delay_2.5 h (young)

rs1535184

36525522

T

C

0.2024

0.02358

1

−0.20769

0.09165

Delay_2.5 h (old)

rs1535183

36525517

A

G

0.2951

0.00853

1

0.1201

0.04565

Delay_1 week (young)

rs73290839

36356451

A

G

0.06818

0.03357

1

0.3082

0.1444

Delay_1 week (old)

rs59989754

36400997

G

A

0.05085

0.00097

0.64

−0.3040

0.09191

Item–item (young)

rs73290827

36335697

T

G

0.06673

0.00169

1

−0.4443

0.1381

Item–item (old)

rs112689619

36278748

T

C

0.05559

0.03147

1

0.1907

0.08881

Item–pair (young)

rs75642402

36423858

T

C

0.06789

0.04421

1

−0.3036

0.1512

Item–pair (old)

rs6126493

36532374

C

T

0.4285

0.00503

1

−0.1174

0.04184

Pair–pair (young)

rs62201726

36543271

G

A

0.1004

0.00186

1

−0.3684

0.1187

Pair–pair (old)

chr20:36283430:D

36283430

TG

T

0.1947

0.15125

1

−0.07110

0.04972

PC1 (young)

rs913966

36309922

G

C

0.06048

0.044565

1

0.8207

0.4070

PC1 (old)

rs73290822

36325944

C

T

0.05165

0.015473

1

−0.4290

0.1770

PC2 (young)

rs913966

36309922

G

C

0.06048

0.01624

1

0.3811

0.1578

PC2 (old)

rs1535183

36525517

A

G

0.2937

0.009717

1

0.1296

0.05010

PC3 (young)

rs66999026

36414507

G

A

0.06705

0.004033

0.7259

−0.4666

0.1597

PC (old)

rs6096781

36527215

T

C

0.05276

0.002951

0.5312

0.2767

0.09290

  1. Abbreviations: A1, allele 1; A2, allele 2; BASE-II, Berlin Aging Study II; MAF, minor allele frequencies in the respective cohort (that is, ‘old’ or ‘young’); P1, P2 and P3 are the first, second and third portion of the recall paradigms; P-adjusted, P-value after adjusting for multiple comparisons (see methods); P-raw, nominal P-value of association statistic; SRFOBK, combined accuracy of forward and backward serial recall tests; SRFO, accuracy of forward serial recall test; SRBK, accuracy of backward serial recall test.
  2. For more detailed descriptions of the tasks and traits, please see Supplementary Methods and Supplementary Table 1. For more details on the administration of these tests, see studies by Lewandowsky et al.,3 Li et al.17 and Papenberg et al.6 Phenotypic means of genotypes AA (1128–1173 old/373–377 young), AG (137–142 old/45–47 young) and GG (4 old/1 young) are shown in columns 2, 3 and 4, respectively. Position is the SNP location on chromosome 20 based on hg19.
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