Table 2 List of the top 20 genes in GC1

From: Genetic association of impulsivity in young adults: a multivariate study

SNP

Gene

Name

CHR

ZS

RW

Function

Associated disease and/or behavior

rs2269426

TNXB a

Tenascin XB

6p21.3

−8.66

1.00

Mediates interactions between cells and extracellular matrix.

SZ

rs2734335

C2

Complement component 2

6p21.3

7.60

0.87

Part of complement system

Autoimmune disease, obesity

rs2072633

RDBP

Negative elongation factor complex member B

6p21.3

7.44

0.85

Regulates elongation of transcription by RNA polymerase

Unknown

rs2559639

CHST11 a

Carbohydrate sulfotransferase 11

12q23.3

6.90

0.79

Catalyzes transfer of sulfate

Marijuana abuse

rs9266231

HLA-B a

MHC class I, B

6p21.3

6.79

0.78

Immune system

MS, SZ, BP

rs2249742

HLA-C a

MHC class I, C

6p21.3

−6.54

0.75

Immune system

Psoriasis, SZ, BP

rs4151657

CFB

Complement factor B

6p21.3

−6.54

0.75

Part of complement system.

SZ

rs3134798

NOTCH4 a

Notch4

6p21.3

6.38

0.73

Cognition, brain development.

SZ, AD, BP

rs6931646

HLA-DRA a

MHC class II, DR alpha

6p21.3

6.12

0.70

Immune system

AD, BP, PD, obesity

rs2844519

MICA

MHC class I polypeptide-related sequence A

6p21.33

5.43

0.62

Antigen presentation.

AD

rs151719

HLA-DMB a

MHC class II, DM beta

6p21.3

5.27

0.60

Peptide loading of MHC class II molecules by helping release the CLIP.

SZ, MS, obesity

rs1787729

DCC a

Deleted in colorectal carcinoma

18q21.3

5.20

0.60

Axon and neuronal guidance.

SZ, depression

rs2741566

PIGT

Phosphatidylinositol glycan anchor biosynthesis, class T

20q12–q13.12

5.01

0.57

Component of GPI transamidase complex

Unknown

rs1511179

CTNNA2 a

Catenin, alpha 2

2p12-p11.1

−4.66

0.53

Cell–cell adhesion and differentiation in nervous system

Excitement seeking/risk taking, AD, ADHD

rs2213565

HLA-DQA2 a

MHC class II, DQ alpha 2

6p21.3

4.62

0.53

Peptide loading of MHC class II beta chain.

Obesity, BP, SZ

rs2544800

SULT2B1

Sulfotransferase family, cytosolic, 2B, member 1

19q13.3

4.61

0.53

Catalyzes sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds

PD

rs1152663

CTBP2 a

C-terminal binding protein 2

10q26.13

4.60

0.53

Targets diverse transcription regulators

TBI

rs9664844

PRKG1 a

Protein kinase, cGMP dependent, type I

10q11.2

4.48

0.51

Nitric oxide/cGMP signaling pathway

SZ, AD

rs3117578

CSNK2B a

Casein kinase 2, beta polypeptide

6p21.3

4.46

0.51

Wnt signaling pathway. Regulates basal catalytic activity of the alpha subunit

Unknown

rs7176717

RORA a

RAR-related orphan receptor A

15q22.2

−4.43

0.51

DA/GLU signaling, circadian rhythms, learning

Autism, PTSD, Depression, BP, MDD

  1. Abbreviations: AD, Alzheimer’s disease; ADHD, attention-deficit hyperactivity disorder; BP, bipolar; CHR, chromosome; CLIP, class II-associated invariant chain peptide; MDD, major depressive disorder; MHC, major histocompatibilty complex; MS, multiple sclerosis; PD, Parkinson’s disease; PTSD, post-traumatic stress disorder; RW, rank weights; SNP, single-nucleotide polymorphism; SZ, schizophrenia; TBI, traumatic brain injury; ZS, Z-score.
  2. Multiple SNP occurrence (>2) in gene network. Information provided was gathered from PubMed, genecards and gene associated databases. Refer to Supplementary Table S4 for detailed references.
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