Table 4 List of top 10 significant pathways for GC1

From: Genetic association of impulsivity in young adults: a multivariate study

Pathways

P-value

q-value

KEGG pathways

  

 Calcium signaling

2.18 × 10−15

4.14 × 10−13

 Arrhythmogenic right ventricular cardiomyopathy

1.90 × 10−14

1.80 × 10−12

 Long-term depression

1.75 × 10−11

1.11 × 10−09

 Circadian entrainment

2.97 × 10−11

1.41 × 10−09

 Cell adhesion molecules

7.24 × 10−11

2.75 × 10−09

 Hypertrophic cardiomyopathy

2.49 × 10−10

7.18 × 10−09

 Pathways in cancer

2.64 × 10−10

7.18 × 10−09

 Cholinergic synapse

4.27 × 10−10

9.61 × 10−09

 MAPK signaling pathway

4.55 × 10−10

9.61 × 10−09

 Retrograde endocannabinoid signaling

7.37 × 10−10

1.40 × 10−08

GeneGo pathways

 Neurophysiological process_ACM regulation of nerve impulse

7.05 × 10−09

4.12 × 10−06

 Immune response_NFAT in immune response

2.51 × 10−08

6.20 × 10−06

 Signal transduction_Activation of PKC via G-protein-coupled receptor

3.18 × 10−08

6.20 × 10−06

 Immune response_BCR

5.01 × 10−08

7.32 × 10−06

 Neurophysiological process_NMDA-dependent postsynaptic long-term potentiation in CA1 hippocampal neurons

9.51 × 10−08

1.11 × 10−05

 Development_Gastrin in differentiation of the gastric mucosa

1.20 × 10−07

1.17 × 10−05

 Immune response_IL-22 signaling

4.97 × 10−07

4.15 × 10−05

 Immune response_Fc epsilon RI

5.74 × 10−07

4.19 × 10−05

 Immune response_CCR5 signaling in macrophages and T lymphocytes

1.01 × 10−06

6.05 × 10−05

 Transport_Alpha-2 adrenergic receptor regulation of ion channels

1.04 × 10−06

6.05 × 10−05

  1. Abbreviations: KEGG, Kyoto Encyclopedia of Genes and Genomes; BCR, B-cell antigen receptor; IL, interleukin; MAPK, mitogen-activated protein kinase; NFAT, nuclear factor of activated T cells; NMDA, N-methyl-D-aspartate; PKC, protein kinase C.
  2. Uncorrected and false-discovery rate corrected P-values are reported in the table.