Figure 2

Regulation of brain responses to positive emotion by ketamine in patients with treatment-resistant depression following ketamine. Left: analysis yielded a single large cluster centered on the right caudate (peak MNI coordinates: 12,21,3; FWE P<0.05). Right: percent signal change extracted from activation cluster at left depicting neural responses to each condition pre- and post-ketamine. BOLD, blood oxygen level-dependent; FWE, family-wise error; MNI, Montreal Neurological Institute.