Table 2 Brain responses during positive emotion task at baseline and following treatment with ketamine

From: Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder

Brain region

X (mm)

Y (mm)

Z (mm)

Cluster extent

Baseline comparison between TRD and healthy groups

 L insula

−24

24

18

398

 R caudate

12

24

6

334

Change in TRD group following ketamine

 R caudate

12

21

3

951

  1. Abbreviations: FWE, family-wise error; L, left; R, right; TRD, treatment-resistant depression.
  2. Clusters indicate regions in which there are significant group (TRD > healthy) × emotion (happy 100% > neutral) or time (Time 2 > Time 1) × emotion (happy 100% > neutral) interactions. Coordinates describe location of cluster peak based on the Montreal Neurological Institute template. For baseline comparison, uncorrected P<0.05, k>170, FWE P<0.05; for treatment effect, uncorrected P<0.05, k>574, FWE P<0.05.
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