Figure 3
From: Functional genomics indicate that schizophrenia may be an adult vascular-ischemic disorder
Functions of schizophrenia-associated genes. The results for genes from the large 2014 GWAS15 and from postmortem studies17 are depicted in a and b, respectively. (a) Vascular (V), ischemic (I), neurodevelopmental (ND) (which are also active during postischemic repair18, 19) and postischemic repair (R) genes appear to have a significant role in the genetic predisposition to schizophrenia. ‘Repair’, ND and R genes combined. (b) The postmortem profile of upregulated vascular-ischemic genes (VI-SY) and downregulated ND and SY genes in the adult brain of schizophrenic patients is compatible with cerebral ischemia. GWAS, genome-wide association study; ND, neurodevelopmental genes; n.s., not significant. Level of significance (Bonferroni corrected, see Supplementary Tables S20 and S21): (a) *P⩽0.01; **P⩽0.001; (b) *P⩽0.05; **P⩽0.01.
