Table 2 Cox regression analyses of risk for use of antidepressants according to 5-HTTLPR biallelic and triallelic genotypes

From: 5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer

Serotonin-transporter-functional genotype

Person-years

Users of antidepressants, n

Unadjusted model

Model 1

Model 2

   

HR

(95% CI)

HR

(95% CI)

HR

(95% CI)

Biallelic genotype (n=806)

 LL

1084

62

1

—

1

—

1

—

 SL

1644

89

0.93

0.7–1.3

0.92

0.7–1.3

0.92

0.7–1.3

 SS

536

29

0.96

0.7–1.5

0.95

0.6–1.5

1.03

0.7–1.6

 Total

3264

180

      

Triallelic genotype (n=793)

 LALA

856

48

1

—

1

—

1

—

 LALG, SLA,

1599

87

0.96

0.7–1.4

0.95

0.7–1.4

0.98

0.7–1.4

 LGLG, SLG, SS

768

42

1.00

0.7–1.5

1.01

0.7–1.5

1.08

0.7–1.6

 Total

3223

177

      
  1. Abbreviations: CI, confidence interval; HR, hazard ratio; 5-HTTLPR, serotonin-transporter-linked polymorphic region.
  2. Model 1: adjusted for age at diagnosis, calendar year at diagnosis and sex.
  3. Model 2: adjusted for age at diagnosis, calendar year at diagnosis, sex, educational level at diagnosis (basic, vocational, high), Charlson Comorbidity Index score at diagnosis (0, 1, +2) and cohabitation status at diagnosis (cohabiting or single).
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