Figure 2

Association of the rs2273500 minor allele (C) with severe vs mild nicotine dependence across all the samples. rs2273500 had the lowest P-value for its association with nicotine dependence in meta-analysis across all the samples, which are sorted by their size. Black-filled diamonds indicate the discovery samples, and open diamonds indicate the replication samples. The odds ratio (OR) estimates are shown proportional to the sample size. CI, confidence interval; COGEND, Collaborative Genetic Study of Nicotine Dependence; COPDGene, Chronic Obstructive Pulmonary Disease Gene Study; EAGLE, Environment and Genetics in Lung Cancer Etiology Study; FTC, Finnish Twin Cohort Study; GAIN, Genetic Association Information Network GWAS of schizophrenia; nonGAIN, Molecular Genetics of Schizophrenia—nonGAIN sample; SAGE*, Study of Addiction: Genetics and Environment (*indicates that overlapping COGEND participants were excluded); UW-TTURC, University of Wisconsin-Transdisciplinary Tobacco Use Research Center.