Table 2 (A) Areas of significant increase and decrease in BOLD response during voluntary emotion regulation (Reappraisal versus Maintain) across both groups. Areas of significant increase in BOLD response in patients versus controls during (B) picture blocks versus fixation baseline blocks, and (C) Maintain versus Reappraisal blocks. MNI coordinates refer to the peak activation voxel of the cluster and main sub-regions within the same cluster (significant group differences are in bold)
BA | Side | Cluster size (voxels) | MNI (x, y, z) | Z-score | P-score | |
|---|---|---|---|---|---|---|
(A) Main effect of task across groups | ||||||
Increased activity during reappraisal (R>M) | ||||||
Dorsal ACC ext. dorsomedial PFC | 6/8/32 | L | 14 701 | −4,20,50 | 5.86 | <0.001 |
Dorsal ACC ext. dorsomedial PFC | 6/8/32 | R | 4,28,40 | 4.99 | ||
Ventrolateral ext. dorsolateral PFC | 9/45/46 | R | 36,46,12 | 4.9 | ||
Cerebellum ext. occipital fusiform/inferior temporal gyri | 19/37 | L | 7 274 | −36,−64,−28 | 4.30 | <0.001 |
Middle temporal gyrus | 20/21 | L | −60,−32,0 | 4.2 | ||
Angular gyrus | 39/40 | R | 44,−60,42 | 4.18 | ||
Superior lateral occipital cortex | 5/7 | R/L | 0,−68,68 | 4.06 | ||
Angular gyrus | 39/40 | L | −60,−44,34 | 4.06 | ||
Cerebellum ext. occipital fusiform/inferior temporal gyri | 19/37 | R | 2 184 | 36,−60,−52 | 4.46 | <0.001 |
Frontal orbital cortex | 11/38 | R | 544 | 16,22,−16 | 3.92 | 0.006 |
Subcallosal cortex ext. caudate | 25 | R | 6,20,−12 | 3.89 | ||
Subcallosal cortex ext. caudate | 25 | L | −4,8,−10 | 3.29 | ||
Decreased activity during reappraisal (M>R) | ||||||
Precuneus ext. lingual gyrus | 19 | R | 477 | 26, − 32,22 | 3.67 | 0.014 |
Precuneus ext. lingual gyrus | 19 | L | 434 | − 20, − 42,24 | 3.90 | 0.024 |
(B) Pictures vs baseline/patients vs controls | ||||||
Dorsal anterior cingulate cortex | 32 | L | 1 352 | − 8,28,38 | 3.99 | <0.001 |
Dorsomedial PFC | 8/9 | L | −24,38,46 | 3.65 | ||
Dorsomedial PFC | 8/9 | R | 4,42,46 | 3.56 | ||
Supplementary motor area | 6 | R/L | 4,14,72 | 3.55 | ||
Dorsolateral PFC | 45 | L | 799 | − 46,30,28 | 3.90 | <0.001 |
Inferior frontal gyrus | 44/48 | L | −54,16,14 | 3.88 | ||
Dorsolateral PFC | 46 | L | −40,34,26 | 3.65 | ||
Dorsolateral PFC | 9 | L | −42,18,44 | 3.50 | ||
Middle temporal gyrus ext. inferior lateral occipital cortex | 20/21 | L | 535 | −56,−28,−12 | 3.77 | 0.003 |
Occipital fusiform gyrus | 37 | L | −48,−66,−12 | 3.53 | ||
Inferior lateral occipital cortex | 19 | L | −44,−74,−14 | 3.33 | ||
Superior lateral occipital cortex | 7 | L | 493 | − 32, − 68,40 | 3.97 | 0.006 |
Angular gyrus | 40 | L | −50,−52,54 | 3.61 | ||
Dorsomedial PFC | 9 | R | 459 | 20,36,54 | 3.30 | 0.009 |
Dorsolateral PFC | 44 | R | 50,18,38 | 3.28 | ||
Dorsolateral PFC | 8/9 | R | 42,18,50 | 3.19 | ||
(C) Maintain vs reappraise/patients vs controls | ||||||
Ventrolateral PFC | 46/47 | R | 417 | 48,56,−2 | 3.98 | 0.030 |
Ventromedial/dorsomedial PFC | 10/11 | R | 32,68,2 | 3.15 | ||
Hippocampus ext. precuneus/posterior cingulate | 27/29/30/37 | R | 387 | 14,−42,4 | 3.80 | 0.044 |
Hippocampus | 27 | R | 24,−34,−12 | 3.65 | ||
Lingual gyrus | 37 | R | 26,−42,−8 | 3.16 | ||
Precuneus | 30 | R | 12,−52,10 | 3.04 | ||
