Figure 2

DBS effects in the novelty-suppressed feeding test (NSFT), forced swim test (FST), elevated plus maze test (EPMT) and open field test (OFT). (a) In the NSFT, latency to feed was significantly higher in stressed animals as compared with non-stressed controls (P=0.0005). DBS applied to stressed animals reduced this latency to near control levels (P=0.005). (b) In the FST, stressed animals presented significantly more immobility than non-stressed controls (P=0.007). DBS applied to stressed animals reduced immobility (P=0.006). (c) In the EPMT, stressed rats spent significantly less time in the open arms (P=0.004 compared with non-stressed controls), an effect that was almost completely reversed by DBS (P=0.004). (d) Neither stress nor DBS induced significant locomotor changes in the OFT. '#' indicates significant differences between stressed rats and non-stressed controls. '*' indicates significant differences between stressed and Stress+DBS animals. Values are means and s.e. Group sizes are indicated in parenthesis. DBS, deep brain stimulation.