Table 3 Univariate analyses
From: Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF
Sociodemographics and lifestyle | Details | Linear regression | ||
|---|---|---|---|---|
Coefficient | Test | P-value | ||
Male | 0.04 (−0.03;0.11) | 1.18 | 0.24 | |
Age | 0.004 (0.001;0.006) | 2.78 | 0.006 | |
Alcohol intake | >20 g per day for females and >30 g per day for males | 0.13 (0.02;0.24) | 2.41 | 0.02 |
Smoking | Present smoker | 0.04 (−0.03;0.11) | 1.02 | 0.31 |
Previous smoker | 0.004 (−0.06;0.06) | 0.13 | 0.9 | |
BMI | 0.01 (0.003;0.01) | 2.98 | 0.003 | |
Physical activity | >4 h per week | −0.06 (−0.12;0.003) | −1.88 | 0.061 |
One experienced SLEs | −0.01 (−0.07;0.05) | −0.26 | 0.8 | |
Two or more experienced SLEs | −0.04 (−0.11;0.03) | −1.05 | 0.29 | |
Health indicators | ||||
Depression | 0.10 (0.05;0.16) | 3.84 | <0.001 | |
Mild | 0.10 (0.03;0.18) | 2.73 | 0.007 | |
Moderate | 0.14 (0.08;0.21) | 4.13 | <0.001 | |
Severe | −0.004 (−0.11;0.10) | −0.08 | 0.93 | |
Previous depressive episodes | 0.06 (0.001;0.12) | 2.00 | 0.05 | |
Previous diagnosed with other mental disorders | −0.01 (−0.15;0.13) | −0.16 | 0.88 | |
Antidepressant treatment | 0.07 (−0.01;0.15) | 1.67 | 0.1 | |
Serum measurements | ||||
Serum VEGF | 2e−4 (1e−4;4e−4) | 4.21 | <0.001 | |
Serum BDNF | 9e−6 (5e−6;1e−5) | 4.64 | <0.001 | |
Genotypes | ||||
rs11581665 | CT genotype | −0.09 (−0.16;−0.03) | −2.84 | 0.005 |
TT genotype | −0.02 (−0.19;0.14) | −0.27 | 0.79 | |
rs12037569 | GT genotype | 0.02 (−0.05;0.08) | 0.49 | 0.63 |
TT genotype | 0.08 (−0.10;0.27) | 0.9 | 0.37 | |
rs17585355 | CA genotype | 0.01 (−0.07;0.10) | 0.34 | 0.74 |
CC genotype | 0.10 (−0.26;0.47) | 0.57 | 0.57 | |
rs17646665 | GA genotype | 0.04 (−0.03;0.11) | 1.07 | 0.29 |
GG genotype | 0.31 (−0.20;0.82) | 1.18 | 0.24 | |
rs3768497 | AA genotype | −0.05 (−0.14;0.04) | −1.07 | 0.29 |
AG genotype | −0.06 (−0.12;−0.007) | −2.22 | 0.027 | |
rs413582 | CT genotype | −0.01 (−0.08;0.05) | −0.39 | 0.7 |
TT genotype | 0.01 (−0.07;0.09) | 0.26 | 0.8 | |
rs464218 | CC genotype | −0.04 (−0.12;0.04) | −0.97 | 0.33 |
CT genotype | −0.03 (−0.09;0.03) | −0.9 | 0.37 | |
rs7536292 | CC genotype | 0.11 (−0.05;0.28) | 1.35 | 0.18 |
CT genotype | −0.0005 (−0.06;0.06) | −0.02 | 0.99 | |
rs6265 (val66met) | AA genotype | 0.006 (−0.11;0.12) | 0.1 | 0.92 |
GA genotype | 0.05 (−0.01;0.10) | 1.55 | 0.12 | |
