Figure 3 | Translational Psychiatry

Figure 3

From: Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: relevance to depression pathophysiology

Figure 3

(a) Disordered pathways affected by altered miRNAs. Various categories of disorders or disease pathways associated with genes that are predicted to be targets of significantly altered miRNAs in the CORT-treated group are shown (P<0.05, Fisher’s Exact Test). (b) Canonical pathways affected by CORT-mediated altered miRNAs. Canonical biological pathways associated with genes that are predicted to be targets of CORT-mediated significantly altered miRNAs is shown (P<0.05, Fisher’s Exact Test). The ratio is calculated as the number of genes in a given pathway divided by the number of genes that make up the pathway. The P-value for a given process annotation is calculated by considering the number of focus genes that participate in that process and the total number of genes that are known to be associated with that process in the selected reference set. The more focus genes involved, the more likely the association is not due to a random chance. CORT, corticosterone; miRNA, microRNA.

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