Figure 1
From: Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance
Spatial learning and recognition memory are enhanced in IFNγ KO mice. (a) Hippocampal-dependent spatial learning was tested in the MWM (IFNγ KO n=23 and WT=26). (b) Hippocampal-dependent non-spatial recognition memory was assessed in the NOR task (IFNγ KO n=12 and WT=12). (c) Prefrontal cortex-dependent behavioural flexibility was assessed in the reversal task (IFNγ KO n=23 and WT=26). Anxiety-like behaviour was assessed using the (d) EPM (IFNγ KO n=7 and WT=10) and (e) OF (IFNγ KO n=7 and WT=10). (f) Motor activity was assessed in the OF (IFNγ KO n=7 and WT=10). Error bars denote s.e.m.; *P<0.05; **P<0.01. EPM, elevated-plus maze; IFNγ, interferon-γ; KO, knockout; MWM, Morris water maze; NOR, novel object recognition; OF, open field; WT, wild type.
