Table 2 Locations and magnitude of brain responses to drug cues before the XRNTX treatment.

From: Neural correlates of adherence to extended-release naltrexone pharmacotherapy in heroin dependence

Region a

BA b

Size

Z-maxc

X d

Y

Z

Drug > Neutral

 Posterior cingulate

29,30

3539

4.75

−1

−44

20

Parahippocampus

28,35

 

3.78

−26

−21

−11

Superior parietal lobule

7

 

3.74

−37

−66

44

Cingulate

23,31

 

3.71

−1

−35

28

 Anterior cingulate

32

786

3.8

−5

44

10

Medial frontal gyrus

10

 

3.65

−5

63

22

 Anterior cingulate

32

 

3.58

14

−64

38

Medial frontal gyrus

10

 

3.25

−5

50

5

Medial frontal gyrus

9

 

3.02

−5

53

21

Medial frontal gyrus

10

 

3.01

−5

57

16

 Occipital gyrus

19

470

3.34

−32

−66

8

Fusiform gyrus

19

 

3.19

−49

−68

−11

Fusiform gyrus

19

 

3.12

−37

−68

−10

Middle occipital/

temporal gyrus

37

 

3.06

−47

−63

−8

Declive

19

 

2.94

−37

−63

−6

Lingual gyrus

18,19

 

2.87

−33

−60

5

  1. Abbreviations: BOLD, blood-oxygen-level dependent; fMRI, functional magnetic resonance imaging; XRNTX, injectable extended-release naltrexone.
  2. Locations of the clusters and the local maxima of BOLD fMRI signal change.
  3. az⩾2.3 and (corrected) cluster significance P<0.05.
  4. bBrodmann’s area.
  5. cZ-max values represent peak activation for the cluster.
  6. dTalairach (1988) coordinates.
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