Table 1 Influence of low activity of tPA and/or protein S on schizophrenia features
From: Dysfunction in the coagulation system and schizophrenia
Low activity of tPA and/or protein S | |
|---|---|
Clinical comorbidity of schizophrenia | Biochemical features of schizophrenia |
Cardiovascular risk | Hypercortisolemia |
Thrombotic tendency | Elevated cytokine levels |
Pregnancy complications | Hyperhomocysteinemia |
Lower-than-expected risk of cancer | Hyperinsulinemia |
Schizophrenia pathogenesis | Hypertriglyceridemia |
Reduced neutrophil | Antiphospholipid antibodies (lupus |
Abnormal NMDA receptor activation | anticoagulant and anticardiolipin antibodies) |
Dopaminergic hypothesis | Low free-protein S levels? |
Adverse fetal environment | |
