Figure 3
Repeated administration of donepezil dose-dependently attenuated nicotine, but not sucrose, self-administration in rats. Total active lever responses (a) and total nicotine infusions (b) are shown for rats pretreated with vehicle (n=11), 0.1 mg kg−1 donepezil (n=11), 1.0 mg kg−1 donepezil (n=12) or 3.0 mg kg−1 donepezil (n=10) before daily nicotine self-administration sessions. On day 1, total active lever responses and total nicotine infusions were significantly decreased in rats pretreated with 1.0 or 3.0 mg kg−1 donepezil compared with vehicle-treated controls (*P<0.05, #P<0.01). On days 2–10, total active lever responses and total nicotine infusions were significantly decreased in rats pretreated with 3.0 mg kg−1 donepezil compared with vehicle-treated controls (*P<0.05, +P<0.001). (c) There were no effects of repeated donepezil administration on sucrose self-administration (n=8, 0 mg kg−1 donepezil; n=8, 1.0 mg kg−1 donepezil; n=9, 3.0 mg kg−1 donepezil).
