Figure 2

Relationship between gray matter concentration (GMC), diagnosis, rs1625579 genotype and miR-137-regulated genetic risk score (GRS). These graphs depict the interaction between the rs1625579 genotype and the miR-137-regulated GRS on structural loading coefficients of component 11, and the directionality of the relationship across diagnostic groups. The solid red lines indicate the best-fit trendline for subjects with the low-risk GG/GT genotype, whereas the solid blue line indicates that of the subjects with the TT or high-risk rs1625579 genotype. The area colored around the lines indicates the respective trend line s.e. The formula for each trendline is indicated on the figure nearest to the respective line. The difference in slope among the healthy control trendlines was nonsignificant (F(1,173)=0.19, P-value=0.7), whereas the difference among the schizophrenia trendlines was found to be significant (F(1,85)=8.95, P-value=3.6x10⁻³).