Table 7 Logistic regression modeling of rs6295 and non-childhood trauma

From: The functional serotonin 1a receptor promoter polymorphism, rs6295, is associated with psychiatric illness and differences in transcription

Non-childhood trauma

Psychiatric hospitalization

Suicide attempt

Past substance abuse

Depression

PTSD

 

OR

P

OR

P

OR

P

OR

P

OR

P

Discovery sample

 rs6295GG

1.655

0.015

1.591

0.026

1.484

0.029

1.209

0.258

1.328

0.095

 Male sex

0.615

0.022

0.300

<0.001

1.703

0.002

0.742

0.078

0.851

0.336

 Age

1.201

0.002

1.229

0.001

1.437

<0.001

1.109

0.018

1.077

0.094

 Age2

0.998

0.005

0.998

0.001

0.996

<0.001

0.999

0.015

0.999

0.072

 Disability

2.454

<0.001

2.178

0.001

1.136

0.534

0.998

0.993

1.178

0.429

 Moderate traumaa

1.964

0.332

4.601

0.053

1.361

0.510

1.238

0.586

1.862

<0.001

 Severe traumaa

4.246

0.018

7.502

0.006

2.485

0.020

2.016

0.035

7.276

<0.001

Test sample

 rs6295GG

2.231

0.007

1.436

0.230

1.163

0.574

    

 Male sex

0.830

0.540

0.506

0.029

1.620

0.056

    

 Age

1.386

<0.001

1.307

0.001

1.434

<0.001

    

 Age2

0.996

<0.001

0.997

0.002

0.996

<0.001

    

 Disability

3.163

0.001

1.946

0.064

1.396

0.274

    

 Moderate traumaa

1.578

0.613

1.055

0.966

1.177

0.862

    

 Severe traumaa

2.254

0.291

5.799

0.090

5.311

0.031

    
  1. Abbreviation: PTSD, posttraumatic stress disorder.
  2. aRelative to no trauma.
  3. Odds ratios (OR) and P-values (P) for P<0.05 are shown in bold.